Improving Health Outcomes in the Tropical North: A Multidisciplinary Collaboration (Hot North)

Melioidosis of the Central Nervous System: Impact of the bimABm Allele on Patient Presentation and Outcome

H Gora, T Hasan, S Smith, I Wilson, M Mayo, C Woerle, JR Webb, BJ Currie, J Hanson, EM Meumann

2024-04-15

Background. The autotransporter protein Burkholderia intracellular motility A (BimA) facilitates the entry of Burkholderia pseudom..

Repurposing antibiotic resistance surveillance data to support treatment of recurrent infections in a remote setting

Will Cuningham, Shalinie Perera, Sonali Coulter, Zhiqiang Wang, Steven YC Tong, Teresa M Wozniak

2024-01-29

In northern Australia, a region with limited access to healthcare and a substantial population living remotely, antibiotic resista..

Genomic databanks provide robust assessment of invasive mosquito movement pathways and cryptic establishment

TL Schmidt, NM Endersby-Harshman, N Kurucz, W Pettit, VL Krause, G Ehlers, MO Muzari, BJ Currie, AA Hoffmann

2023-11-01

Biosecurity strategies that aim to restrict the spread of invasive pests can benefit from knowing where incursions have come from ..

Child linear growth trajectories during the first three years of life in relation to infant iron status: a prospective cohort study in rural Vietnam

S Hanieh, S Braat, TD Tran, TT Ha, JA Simpson, T Tuan, J Fisher, BA Biggs

2022-12-01

Background: Early childhood growth patterns have long-term consequences for health and disease. Little is known about the interpla..

Diagnostic performance of a 5-plex malaria immunoassay in regions co-endemic for Plasmodium falciparum, P. vivax, P. knowlesi, P. malariae and P. ovale

S Kho, NM Anstey, BE Barber, K Piera, T William, E Kenangalem, JS McCarthy, IK Jang, GJ Domingo, S Britton, MJ Grigg

2022-12-01

Commercial point-of-care tests remain insufficient for accurately detecting and differentiating low-level malaria infections in re..

Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

MKD Rodrigo, A Saiganesh, AJ Hayes, AM Wilson, J Anstey, JL Pickering, J Iwasaki, J Hillas, S Winslow, T Woodman, P Nitschke, JA Lacey, KJ Breese, MPG van der Linden, PM Giffard, SYC Tong, N Gray, KA Stubbs, JR Carapetis, AC Bowen

2022-12-01

Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by i..

Phylodynamic signatures in the emergence of community-associated MRSA

E Steinig, I Aglua, S Duchene, MT Meehan, M Yoannes, C Firth, J Jaworski, J Drekore, B Urakoko, H Poka, C Wurr, E Ebos, D Nangen, E Müller, P Mulvey, C Jackson, A Blomfeldt, HV Aamot, M Laman, L Manning

2022-11-08

Community-associated, methicillin-resistant Staphylococcus aureus (MRSA) lineages have emerged in many geographically distinct reg..

Melioidosis in the remote Katherine region of northern Australia

K Hodgetts, M Kleinecke, C Woerle, M Kaestli, R Budd, JR Webb, L Ward, M Mayo, BJ Currie, EM Meumannid

2022-06-01

Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, s..

Genomic Epidemiology Links Burkholderia pseudomallei from Individual Human Cases to B. pseudomallei from Targeted Environmental Sampling in Northern Australia

JR Webb, M Mayo, A Rachlin, C Woerle, E Meumann, V Rigas, G Harrington, M Kaestli, BJ Currie

2022-03-01

Each case of melioidosis results from a single event when a human is infected by the environmental bacterium Burkholderia pseudoma..

Phylodynamic Inference of Bacterial Outbreak Parameters Using Nanopore Sequencing

E Steinig, S Duchêne, I Aglua, A Greenhill, R Ford, M Yoannes, J Jaworski, J Drekore, B Urakoko, H Poka, C Wurr, E Ebos, D Nangen, L Manning, M Laman, C Firth, S Smith, W Pomat, SYC Tong, L Coin

2022-03-01

Nanopore sequencing and phylodynamic modeling have been used to reconstruct the transmission dynamics of viral epidemics, but thei..

Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE) - An open-labelled pilot randomized controlled trial

AJ Campbell, R Dotel, M Braddick, PN Britton, DP Eisen, JR Francis, S Lynar, B McMullan, N Meagher, J Nelson, MVN O'Sullivan, DJ Price, JO Robinson, A Whelan, SYC Tong, AC Bowen, JS Davis

2022-02-01

Background: Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe..

The Darwin Prospective Melioidosis Study: a 30-year prospective, observational investigation

BJ Currie, M Mayo, LM Ward, M Kaestli, EM Meumann, JR Webb, C Woerle, RW Baird, RN Price, CS Marshall, AP Ralph, E Spencer, J Davies, SE Huffam, S Janson, S Lynar, P Markey, VL Krause, NM Anstey

2021-12-01

Background: The global distribution of melioidosis is under considerable scrutiny, with both unmasking of endemic disease in Afric..

Tuberculosis in Australia's tropical north: a population-based genomic epidemiological study

EM Meumann, K Horan, AP Ralph, B Farmer, M Globan, E Stephenson, T Popple, R Boyd, M Kaestli, T Seemann, K Vandelannoote, C Lowbridge, RW Baird, TP Stinear, DA Williamson, BJ Currie, VL Krause

2021-10-01

Background: The Northern Territory (NT) has the highest tuberculosis (TB) rate of all Australian jurisdictions. We combined TB pub..

Antibiotic resistance in uropathogens across northern Australia 2007-20 and impact on treatment guidelines

W Cuningham, S Perera, S Coulter, GR Nimmo, T Yarwood, SYC Tong, TM Wozniak

2021-09-01

Background: Urinary tract infections are common and are increasingly resistant to antibiotic therapy. Northern Australia is a spar..

Unique knowledge, unique skills, unique role: Aboriginal and Torres Strait Islander Health Workers in Queensland, Australia

SM Topp, J Tully, R Cummins, V Graham, A Yashadhana, L Elliott, S Taylor

2021-07-02

Aboriginal and Torres Strait Islander Health Workers (A and TSIHWs) are a professional cadre of Australian health workers typicall..

Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the sarcoptes scabiei genome

L Chng, DC Holt, M Field, JR Francis, D Tilakaratne, MH Dekkers, G Robinson, K Mounsey, R Pavlos, AC Bowen, K Fischer, AT Papenfuss, RB Gasser, PK Korhonen, BJ Currie, JS McCarthy, C Pasay

2021-02-01

Background The suboptimal sensitivity and specificity of available diagnostic methods for scabies ham-pers clinical management, tr..

Using Land Runoff To Survey the Distribution and Genetic Diversity of Burkholderia pseudomallei Strains in Vientiane, Laos

A Rachlin, M Luangraj, M Kaestli, S Rattanavong, P Phoumin, JR Webb, M Mayo, BJ Currie, DAB Dance

2021-02-01

Melioidosis is a disease of significant public health importance that is being increasingly recognized globally. The majority of c..

Genomic epidemiology of tuberculosis in eastern Malaysia: Insights for strengthening public health responses

A Bainomugisa, EM Meumann, GS Rajahram, RTH Ong, L Coin, DC Paul, T William, C Coulter, AP Ralph

2021-01-01

Tuberculosis is a leading public health priority in eastern Malaysia. Knowledge of the genomic epidemiology of tuberculosis can he..

Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei

DE Madden, JR Webb, EJ Steinig, BJ Currie, EP Price, DS Sarovich

2021-01-01

Background: Antimicrobial resistance (AMR) poses a major threat to human health. Whole-genome sequencing holds great potential for..

Myanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries

JR Webb, MM Win, KN Zin, KKN Win, TT Wah, EA Ashley, F Smithuis, MMM Swe, M Mayo, BJ Currie, DAB Dance

2020-12-01

Melioidosis was first identified in Myanmar in 1911 but for the last century it has remained largely unreported there. Burkholderi..

Whole-genome sequencing of Burkholderia pseudomallei from an urban melioidosis hot spot reveals a fine-scale population structure and localised spatial clustering in the environment

A Rachlin, M Mayo, JR Webb, M Kleinecke, V Rigas, G Harrington, BJ Currie, M Kaestli

2020-12-01

Melioidosis is a severe disease caused by the environmental bacterium Burkholderia pseudomallei that affects both humans and anima..

A Persisting Nontropical Focus of Burkholderia pseudomallei with Limited Genome Evolution over Five Decades

JR Webb, N Buller, A Rachlin, C Golledge, DS Sarovich, EP Price, M Mayo, BJ Curriea

2020-11-10

Burkholderia pseudomallei is the causative agent of the high-mortality disease melioidosis. Although melioidosis is classified as ..

A model of population dynamics with complex household structure and mobility: Implications for transmission and control of communicable diseases

RH Chisholm, B Crammond, Y Wu, AC Bowen, PT Campbell, SYC Tong, J McVernon, N Geard

2020-11-03

Households are known to be high-risk locations for the transmission of communicable diseases. Numerous modelling studies have demo..

Safer in Vitro Drug Screening Models for Melioidosis Therapy Development

AS Amiss, JR Webb, M Mayo, BJ Currie, DJ Craik, ST Henriques, N Lawrence

2020-11-01

Melioidosis is a neglected tropical disease caused by the Gram-negative soil bacterium Burkholderia pseudomallei. Current antibiot..

Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data From Malaria Volunteer Infection Studies

Leesa F Wockner, Isabell Hoffmann, Lachlan Webb, Benjamin Mordmueller, Sean C Murphy, James G Kublin, Peter O'Rourke, James S McCarthy, Louise Marquart

2020-03-15

Background Growth rate of malaria parasites in the blood of infected subjects is an important measure of efficacy of drugs and vac..

Melioidosis fatalities in captive slender-tailed meerkats (Suricata suricatta): Combining epidemiology, pathology and whole-genome sequencing supports variable mechanisms of transmission with one health implications

A Rachlin, C Shilton, JR Webb, M Mayo, M Kaestli, M Kleinecke, V Rigas, S Benedict, I Gurry, BJ Currie

2019-12-19

Background: Melioidosis is a tropical infectious disease which is being increasingly recognised throughout the globe. Infection oc..

The Stunting Tool for Early Prevention: Development and external validation of a novel tool to predict risk of stunting in children at 3 years of age

S Hanieh, S Braat, JA Simpson, TTT Ha, TD Tran, T Tuan, J Fisher, BA Biggs

2019-11-01

Introduction Globally, an estimated 151 million children under 5 years of age still suffer from the adverse effects of stunting. W..

Tracing the environmental footprint of the Burkholderia pseudomallei lipopolysaccharide genotypes in the tropical “Top End” of the Northern Territory, Australia

JR Webb, A Rachlin, V Rigas, DS Sarovich, EP Price, M Kaestli, LM Ward, M Mayo, BJ Currie

2019-07-01

The Tier 1 select agent Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a high mortality disease...

Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in papua, indonesia: A longitudinal surveillance study

E Kenangalem, JR Poespoprodjo, NM Douglas, FH Burdam, K Gdeumana, F Chalfein, null Prayoga, F Thio, A Devine, J Marfurt, G Waramori, S Yeung, R Noviyanti, P Penttinen, MJ Bangs, P Sugiarto, JA Simpson, Y Soenarto, NM Anstey, RN Price

2019-05-01

Background Malaria control activities can have a disproportionately greater impact on Plasmodium falciparum than on P. vivax in ar..

Bridging the knowledge-practice gap in tuberculosis contact management in a high-burden setting: a mixed-methods protocol for a multicenter health system strengthening study

T Lestari, S Graham, C Van den Boogard, R Triasih, JR Poespoprodjo, RR Ubra, E Kenangalem, Y Mahendradhata, NM Anstey, RS Bailie, AP Ralph

2019-03-19

Background: People in close contact with tuberculosis should have screening and appropriate management, as an opportunity for acti..

A cluster of melioidosis infections in hatchling saltwater crocodiles (Crocodylus porosus) resolved using genomewide comparison of a common north Australian strain of burkholderia pseudomallei

A Rachlin, M Kleinecke, M Kaestli, M Mayo, JR Webb, V Rigas, C Shilton, S Benedict, K Dyrting, BJ Currie

2019-01-01

Burkholderia pseudomallei is a Gram-negative saprophytic bacillus and the aetiological agent of melioidosis, a disease of publiche..

Opportunistic pathogens and large microbial diversity detected in source-to-distribution drinking water of three remote communities in Northern Australia

M Kaestli, M O'Donnell, A Rose, JR Webb, M Mayo, BJ Currie, K Gibb

2019-01-01

In the wet-dry tropics of Northern Australia, drinking water in remote communities is mostly sourced from bores accessing groundwa..

The clinical, immunological and microbiological impact of the 10-valent pneumococcal-Protein D conjugate vaccine in children with recurrent protracted bacterial bronchitis, chronic suppurative lung disease and bronchiectasis: A multi-centre, double-blind, randomised controlled trial

KAF O'Grady, AB Chang, A Cripps, EK Mulholland, H Smith-Vaughan, N Wood, M Danchin, R Thornton, A Wilson, PJ Torzillo, PM Morris, P Richmond, S Rablin, D Arnold, A Connor, V Goyal, T Stoney, K Perrett, K Grimwood

2018-11-02

We aimed to determine the efficacy of the 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in c..

Raising the stakes: Loss of efflux pump regulation decreases meropenem susceptibility in burkholderia pseudomallei

DS Sarovich, JR Webb, MC Pitman, LT Viberg, M Mayo, RW Baird, JM Robson, BJ Currie, EP Price

2018-07-02

Background Burkholderia pseudomallei, the causative agent of the high-mortality disease melioidosis, is a gram-negative bacterium ..

Phylogeographic, genomic, and meropenem susceptibility analysis of Burkholderia ubonensis

EP Price, DS Sarovich, JR Webb, CM Hall, SA Jaramillo, JW Sahl, M Kaestli, M Mayo, G Harrington, AL Baker, LC Sidak-Loftis, EW Settles, M Lummis, JM Schupp, JD Gillece, A Tuanyok, J Warner, JD Busch, P Keim, BJ Currie

2017-09-14

The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Bur..

Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections including Impetigo, Cellulitis, and Abscess

AC Bowen, JR Carapetis, BJ Currie, V Fowler, HF Chambers, SYC Tong

2017-01-01

Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory car..